Anti-Zebrafish Sf3b4 / Splicing factor 3B subunit 4

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Predicted to enable RNA binding activity. Acts upstream of or within regulation of retina development in camera-type eye and visual behavior. Predicted to be located in nucleus. Predicted to be part of U2 snRNP and precatalytic spliceosome. Is expressed in head. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis, cervical cancer, and hepatocellular carcinoma. Orthologous to human SF3B4 (splicing factor 3b subunit 4). Protein function: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre- mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. [The UniProt Consortium]