Anti-Zebrafish Hspa5 / Grp78 / Bip

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Heat shock 70 kDa protein 5 (Hspa5), also known as GRP78 (Glucose-Regulated Protein 78) or BiP (Binding Immunoglobulin Protein), is a highly conserved member of the HSP70 family of molecular chaperones. In zebrafish (Danio rerio), hspa5 encodes an endoplasmic reticulum (ER)-resident chaperone that plays a central role in protein quality control, particularly during ER stress and the unfolded protein response (UPR).Hspa5 facilitates proper protein folding, prevents aggregation of misfolded proteins, and targets irreversibly misfolded proteins for degradation. It is also a key regulator of ER homeostasis, acting as a sensor for misfolded proteins and an upstream effector in activating UPR pathways, including PERK, ATF6, and IRE1.