Anti-Zebrafish Dmrt1 / Doublesex and mab 3 related transcription factor 1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene. This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. Protein function: Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator. [The UniProt Consortium]