Anti-Zebrafish Ascl1a / Achaete-scute homolog 1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Achaete-scute family bHLH transcription factor 1a (Ascl1a) is a basic helix-loop-helix (bHLH) transcription factor that plays a crucial role in neurogenesis and cell fate determination. In zebrafish (Danio rerio), Ascl1a is a key regulator of neural progenitor proliferation and differentiation, particularly within the central nervous system, retina, and intestinal epithelium.Ascl1a acts downstream of proneural signaling pathways and promotes the commitment of progenitor cells to a neuronal lineage. It is expressed in neural precursor cells during embryonic development and is reactivated in regenerative contexts. In the zebrafish retina and brain, Ascl1a is essential for the regeneration of neurons following injury, making it a prominent factor in regenerative neurobiology.Zebrafish Ascl1a is widely used as a model for studying the molecular mechanisms of neuronal differentiation, stem cell biology, and tissue regeneration. Its expression is tightly regulated by signaling pathways such as Notch, and its function is conserved across vertebrates, including in mammalian neurogenesis.