Anti-ZCCHC6

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A305-088A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A305-088A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short... more

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Product information "Anti-ZCCHC6"

Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult. [The UniProt Consortium]

Keywords:	Anti-HS2, Anti-ZCCHC6, Anti-TUTase 7, EC=2.7.7.52, Anti-Terminal uridylyltransferase 7, Anti-Zinc finger CCHC domain-containing protein 6
Supplier:	Bethyl Laboratories
Supplier-Nr:	A305-088A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: gorilla, chimpanzee)
Immunogen:	synthetic peptide. The epitope recognized by A305-088A-T maps to a region between residue 75 to 125 of human Terminal uridylyltransferase 7 using the numbering given in entry Q5VYS8.1 (GeneID 79670).
Format:	Antigen Affinity Purified