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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-635A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A302-635A | 100 µl | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short... more
Product information "Anti-ZCCHC11"
Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency. Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult. [The UniProt Consortium]
Keywords: | Anti-ZCCHC11, Anti-TUTase 4, Anti-KIAA0191, EC=2.7.7.52, Anti-Terminal uridylyltransferase 4, Anti-Zinc finger CCHC domain-containing protein 11 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-635A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: orangutan, chimpanzee, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A302-635A-T maps to a region between residue 1 and 50 of human zinc finger, CCHC domain containing 11 using the numbering given in entry NP_056084.1 (GeneID 23318). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K13291 | Matching products |
UniProt ID : | Q5TAX3 | Matching products |
Gene ID | GeneID 23318 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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