Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-635A-T 20 µl (2 blots) -

3 - 9 business days*

A302-635A-M 100 µl (10 blots) -

3 - 9 business days*

A302-635A 100 µl (20 µg) -

3 - 9 business days*

Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short... more
Product information "Anti-ZCCHC11"
Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency. Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult. [The UniProt Consortium]
Keywords: Anti-ZCCHC11, Anti-TUTase 4, Anti-KIAA0191, EC=, Anti-Terminal uridylyltransferase 4, Anti-Zinc finger CCHC domain-containing protein 11
Supplier: Bethyl Laboratories
Supplier-Nr: A302-635A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-635A-T maps to a region between residue 1 and 50 of human zinc finger, CCHC domain containing 11 using the numbering given in entry NP_056084.1 (GeneID 23318).
Format: Antigen Affinity Purified

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