Anti-YY1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-779A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-779A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-779A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Multifunctional transcription factor that exhibits positive and negative... more
Product information "Anti-YY1"
Protein function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'- GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). [The UniProt Consortium]
Keywords: Anti-YY1, Anti-YY-1, Anti-NF-E1, Anti-INO80S, Anti-Yin and yang 1, Anti-INO80 complex subunit S, Anti-Delta transcription factor, Anti-Transcriptional repressor protein YY1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-779A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Sheep, Bovine, Dog, Rhesus Monkey, Gorilla, White-tufted-ear Marmoset, European Domestic Ferret)
Immunogen: synthetic peptide. The epitope recognized by A302-779A-T maps to a region between residue 50 and 100 of human Yin and Yang 1 Protein using the numbering given in entry NP_003394.1 (GeneID 7528).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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