Anti-WT1 / Wilms Tumor 1, clone WT1/1434R (recombinant antibody)

Anti-WT1 / Wilms Tumor 1, clone WT1/1434R (recombinant antibody)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7263SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Wilms tumor is associated with mutations of WT1,... more
Product information "Anti-WT1 / Wilms Tumor 1, clone WT1/1434R (recombinant antibody)"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Wilms tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas. Protein function: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). [The UniProt Consortium]
Keywords: Anti-WT1, Anti-WT33, Anti-Wilms tumor protein, Recombinant WT1 Antibody / Wilms Tumor 1
Supplier: NSJ Bioreagents
Supplier-Nr: V7263SAF-100UG

Properties

Application: IF, IHC (paraffin), FC
Antibody Type: Monoclonal
Clone: WT1/1434R
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: A recombinant protein was used as the immunogen for the recombinant WT1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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