Anti-WT1 / Wilms tumor 1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG66514.100	100 µl		-	-	6 - 14 business days*		584.00€

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Protein function: Transcription factor that plays an important role in cellular development and... more

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Product information "Anti-WT1 / Wilms tumor 1"

Protein function: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). [The UniProt Consortium]

Keywords:	Anti-WT1, Anti-WT33, Anti-Wilms tumor protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG66514

Properties

Application:	IHC (paraffin)
Antibody Type:	Monoclonal
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Synthetic peptide derived from Human WT1 / Wilms tumor 1
Format:	Antigen Affinity Purified