Anti-WT1 Cocktail (Wilms Tumor 1), clone WT1/857 + 6F-H2

Anti-WT1 Cocktail (Wilms Tumor 1), clone WT1/857 + 6F-H2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2933SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a 47-55kDa-tumor suppressor... more
Product information "Anti-WT1 Cocktail (Wilms Tumor 1), clone WT1/857 + 6F-H2"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas. Protein function: Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. [The UniProt Consortium]
Keywords: Anti-WT1, Anti-WT33, Anti-Wilms tumor protein, WT1 Antibody Cocktail (Wilms Tumor 1)
Supplier: NSJ Bioreagents
Supplier-Nr: V2933SAF-100UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Mixed
Clone: WT1/857+6F-H2
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant full length human WT1 protein (WT1/857), A partial WT1 recombinant protein (aa 1-181) (6F-H2)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-WT1 Cocktail (Wilms Tumor 1), clone WT1/857 + 6F-H2"
Write a review
or to review a product.
Viewed