Anti-WNK1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-514A-T	10 µl (2 µg)		-		2 - 8 business days*		178.00€
A301-514A	100 µl		-		2 - 8 business days*		630.00€

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Protein function: Serine/threonine kinase which plays an important role in the regulation of... more

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Product information "Anti-WNK1"

Protein function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. [The UniProt Consortium]

Keywords:	Anti-p65, Anti-hWNK1, Anti-Kinase deficient protein, Anti-Erythrocyte 65 kDa protein, Anti-Protein kinase with no lysine 1, Anti-Protein kinase lysine-deficient 1, Anti-Serine/threonine-protein kinase WNK1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-514A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A301-514A-T maps to a region between residue 1625 and 1675 of human WNK lysine deficient protein kinase 1 using the numbering given in entry NP_061852.2 (GeneID 65125).
Format:	Antigen Affinity Purified