Anti-WIPI2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA019852.25	25 µl		-		7 - 10 business days*		246.00€
ATA-HPA019852.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Component of the autophagy machinery that controls the major intracellular... more

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Product information "Anti-WIPI2"

Protein function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3- phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12- ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 83% and to rat: 84%

Keywords:	Anti-WIPI2, Anti-CGI-50, Anti-WIPI-2, Anti-WIPI49-like protein 2, Anti-WD repeat domain phosphoinositide-interacting protein 2
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA019852

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: ECALMKQHRL DGSLETTNEI LDSASHDCPL VTQTYGAAAG KGTYVPSSPT RLAYTDDLGA VGGACLEDEA SALRLDEDSE HPPMILRTD (ATA-APrEST75037)