Anti-WEE1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG55245.50	50 µl		-	-	6 - 14 business days*		432.00€
ARG55245.100	100 µl		-	-	6 - 14 business days*		616.00€

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Protein function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by... more

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Product information "Anti-WEE1"

Protein function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. [The UniProt Consortium]

Keywords:	Anti-WEE1, Anti-WEE1hu, EC=2.7.10.2, Anti-Wee1A kinase, Anti-Wee1-like protein kinase
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG55245

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	KLH-conjugated synthetic peptide around aa. 144-173 (Center) of Human WEE1
Format:	Purified