Anti-WDR37 / WD repeat-containing protein 37

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. WDR37 antibody detects WD repeat-containing protein 37, a member of the WD40 domain protein family that serves as a scaffolding component in numerous multiprotein complexes. WD repeat proteins coordinate protein-protein interactions and are involved in processes such as vesicular trafficking, signal transduction, RNA processing, and cell cycle regulation. WDR37 is conserved across species and is characterized by multiple WD40 repeats forming a beta-propeller structure that mediates molecular recognition events. The WDR37 antibody is valuable for studies exploring signal transduction pathways, protein complex assembly, and developmental regulation.WDR37 is encoded by the WDR37 gene located on human chromosome 10p15.1. The protein is ubiquitously expressed, with higher levels in brain, kidney, and reproductive tissues. Its precise molecular function remains under investigation, but emerging evidence suggests roles in intracellular signaling and vesicle trafficking. Mutations in WDR37 have been linked to a congenital neurodevelopmental disorder featuring craniofacial and ocular anomalies, underscoring its importance in human development. Studies in animal models indicate that Wdr37 contributes to ciliary and cytoskeletal organization, reflecting a potential connection to ciliopathies.Using the WDR37 antibody, researchers can detect the native ~55 kDa protein via western blot and localize it through immunofluorescence microscopy. Expression analysis demonstrates cytoplasmic and perinuclear localization, consistent with a role in vesicular trafficking. The antibody is also useful in co-immunoprecipitation experiments for identifying interacting partners within signaling and transport complexes. Functional studies are beginning to connect WDR37 with cell cycle progression and protein degradation pathways, suggesting a role in maintaining proteostasis.WD repeat proteins like WDR37 often act as adaptors within ubiquitin ligase complexes, G-protein signaling pathways, or RNA splicing assemblies. Understanding WDR37 biology could shed light on how these complexes maintain cellular organization and developmental homeostasis. NSJ Bioreagents provides a validated WDR37 antibody optimized for western blot and immunocytochemistry, supporting ongoing research into WD40 domain protein function, developmental biology, and molecular pathology.