Anti-WDR26 / WD repeat domain-containing protein 26

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. WDR26 antibody detects WD repeat domain-containing protein 26, a multifunctional adaptor protein that participates in G protein-coupled receptor (GPCR) signaling, cytoskeletal regulation, and cell proliferation. Encoded by the WDR26 gene on chromosome 1q42.11, this protein contains several WD40 repeats that form a beta-propeller structure facilitating protein-protein interactions. WDR26 functions as a scaffold that coordinates signal transduction and cytoskeletal rearrangements downstream of heterotrimeric G proteins and growth factor receptors.WDR26 localizes to both the cytoplasm and plasma membrane, where it binds Gbetagamma subunits and regulates downstream effectors such as PI3K, AKT, and ERK. By modulating these pathways, it controls cell migration, survival, and proliferation. Additionally, WDR26 plays roles in vesicle trafficking, stress response, and cell morphology through interactions with actin-associated proteins.The WDR26 antibody is used in signaling, oncology, and molecular biology research to investigate scaffolding functions and GPCR-mediated pathways. Western blot analysis identifies a 65 kilodalton band corresponding to WDR26, while immunofluorescence shows cytoplasmic and membrane-associated staining. This antibody supports the study of protein complexes that regulate cellular communication and structure.Aberrant expression of WDR26 has been linked to cancer progression and inflammatory signaling. Elevated WDR26 enhances AKT phosphorylation and cell survival, contributing to chemoresistance and metastasis, while loss of expression disrupts signaling coordination. The WDR26 antibody provides a valuable tool for exploring these mechanisms in disease and cellular physiology. NSJ Bioreagents validates this antibody for its applications, ensuring reliable performance in GPCR and signal transduction studies.