Anti-von Willebrand Factor / vWF (recombinant antibody), clone VWF/1859R

Anti-von Willebrand Factor / vWF (recombinant antibody), clone VWF/1859R
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3491IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. von... more
Product information "Anti-von Willebrand Factor / vWF (recombinant antibody), clone VWF/1859R"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen. Protein function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. [The UniProt Consortium]
Keywords: Anti-VWF, Anti-F8VWF, Recombinant von Willebrand Factor / vWF Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3491IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: VWF/1859R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Amino acids 1815-1939 from the human protein were used as the immunogen for this recombinant vWF antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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