Anti-Vimentin / VIM, clone MSVA-458R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Vimentin (VIM) is a type III intermediate filament protein that plays a central role in maintaining cytoskeletal integrity and cellular architecture in mesenchymal cells. It is highly expressed in fibroblasts, endothelial cells, and stromal compartments, where it contributes to mechanical stability and intracellular organization. Vimentin, also referred to as VIM antibody or Vimentin antibody in the literature, is widely used as a definitive marker for mesenchymal cell identification in tissue sections.The VIM Antibody for IHC / Vimentin Immunohistochemistry Antibody is specifically developed for immunohistochemistry-based detection of Vimentin in formalin-fixed, paraffin-embedded tissues, with strong emphasis on producing clean, interpretable staining patterns in complex tissue environments. This VIM antibody for IHC enables clear visualization of stromal architecture and mesenchymal cell distribution, making it highly effective for distinguishing epithelial versus mesenchymal compartments in histological analysis. The recombinant rabbit monoclonal clone MSVA-458R provides consistent staining intensity and reproducibility across different tissue types.A defining strength of this VIM Antibody for IHC is its extensive validation on human tissue microarrays (TMA), where large panels of normal and cancer tissues are evaluated in parallel. In these TMA datasets, the Vimentin immunohistochemistry antibody demonstrates staining patterns that closely match established biological expression profiles, including strong cytoplasmic staining in stromal and mesenchymal cells and minimal staining in epithelial regions. This alignment with known tissue distribution supports confident interpretation in IHC workflows and reinforces its reliability in both research and pathology-focused studies.The TMA-driven performance of this VIM antibody for IHC highlights its suitability for high-throughput tissue analysis, where consistency across diverse tissue types is critical. The ability to maintain clear signal-to-background contrast across multiple cores within a single array makes this antibody particularly valuable for comparative studies, biomarker screening, and tissue profiling applications that rely on immunohistochemistry.Functionally, Vimentin is involved in cytoskeletal organization, cellular resilience, and structural adaptation to environmental changes. It is also associated with processes such as epithelial-to-mesenchymal transition, wound repair, and cellular migration, all of which are commonly evaluated using immunohistochemistry. The Vimentin immunohistochemistry antibody therefore provides a reliable means of visualizing these biological processes directly within tissue architecture.This VIM Antibody for IHC is uniquely positioned for tissue-based applications where high-quality staining, reproducibility, and biological accuracy are essential. Its strong performance in TMA studies, combined with clear and consistent staining patterns, makes it a robust choice for immunohistochemistry workflows requiring dependable detection of Vimentin across a wide range of normal and disease-associated tissues.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.