Anti-Vimentin (Mesenchymal Cell Marker), clone VM452

Formulation: Purified Ab conjugated to CF488. Cellular Localization: Cell membrane, Cytoplasm, Cytoskeleton, Nucleus matrix. Positive Control: Raji, A375, Jurkat cells, Human Melanomas. Chromosome Location: 10p12.33. Protein Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity) , Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 [The Uniprot Consortium]