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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay20197-100 | 100 µg | - |
6 - 10 business days* |
535.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Vimentin is a cytoskeleton intermediate filament protein. It is composed of monomers that each... more
Product information "Anti-Vimentin (Clone 12E4)"
Vimentin is a cytoskeleton intermediate filament protein. It is composed of monomers that each contain a central alpha-helix rod domain, which facilitates formation of a coiled-coil dimer required for vimentin filament assembly, as well as N-terminal head and C-terminal tail domains. It is expressed in mesenchymal stem cells and cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol. It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity. Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites. It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center. Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs). ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases. Cayman's Vimentin Monoclonal Antibody (Clone 12E4) can be used for ELISA, immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes vimentin at approximately 54 kDa from human samples.Synonyms: VIM. Immunogen: Recombinant human vimentin. Clone Designation: 12E4. MW: ~54 kDa. Formulation: (Request formulation change), 100 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG2a. Applications: ELISA, IP, WB. Cross Reactivity: (+) Vimentin, (+) Citrullinated vimentin. UniProt Accession #: P08670.
Keywords: | Anti-VIM, Anti-Vimentin, Anti-Vimentin |
Supplier: | Cayman Chemical |
Supplier-Nr: | 20197 |
Properties
Application: | ELISA, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 12E4 |
Conjugate: | No |
Host: | Mouse |
Immunogen: | Recombinant human vimentin |
MW: | 57 kD |
Format: | Purified |
Database Information
KEGG ID : | K07606 | Matching products |
UniProt ID : | P08670 | Matching products |
Gene ID | GeneID 7431 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H319 |
P Phrases: | P264, P280, P305+351+338, P332+313, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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