Anti-VGluT2 / Vesicular glutamate transporter 2 / SLC17A6

In 1X PBS, pH 7.4, with 0.09% sodium azide. VGluT2, short for Vesicular Glutamate Transporter 2, is a protein that is responsible for packaging and transporting glutamate into synaptic vesicles. These vesicles then release glutamate into the synaptic cleft, where it binds to receptors on the postsynaptic neuron, leading to the transmission of signals between neurons. Research has shown that VGluT2 is predominantly expressed in specific brain regions, such as the cerebellum, hippocampus, and cortex, where it plays a crucial role in modulating synaptic transmission and plasticity. Dysfunction of VGluT2 has been linked to various neurological disorders, including epilepsy, schizophrenia, and neurodegenerative diseases. Protein function: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11432869, PubMed:17108179, PubMed:25433636, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11432869, PubMed:17108179). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)- ATPase across the synaptic vesicle membrane (PubMed:11432869). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed:25433636). The vesicular H(+)/H(+) antiport activity is electroneutral (PubMed:25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:33440152). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:33440152). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (PubMed:30936473). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. [The UniProt Consortium]