Anti-VEGFR1, clone VGR1T-1

Anti-VEGFR1, clone VGR1T-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7024-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V7024-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Protein function: Tyrosine-protein... more
Product information "Anti-VEGFR1, clone VGR1T-1"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain, it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. [The UniProt Consortium]
Keywords: Anti-FLT, Anti-FLT1, Anti-FLT-1, Anti-VEGFR-1, EC=2.7.10.1, Anti-Fms-like tyrosine kinase 1, Anti-Tyrosine-protein kinase FRT, Anti-Tyrosine-protein kinase receptor FLT, Anti-Vascular permeability factor receptor
Supplier: NSJ Bioreagents
Supplier-Nr: V7024

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: VGR1T-1
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant human protein was used as the immunogen for this VEGFR1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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