Anti-USP5 / Ubiquitin carboxyl-terminal hydrolase 5

0.5mg/ml if reconstituted with 0.2ml sterile DI water. USP5 (Ubiquitin carboxyl-terminal hydrolase 5) is a member of the deubiquitinating enzyme (DUB) family, which plays a central role in regulating protein stability and turnover by processing ubiquitin chains. USP5 specifically disassembles unanchored polyubiquitin chains into monoubiquitin, maintaining a sufficient pool of free ubiquitin necessary for cellular homeostasis. A USP5 antibody is widely used to study protein degradation, ubiquitin recycling, and regulatory pathways involving the proteasome. USP5, sometimes referred to as Isopeptidase T, functions in close connection with the ubiquitin-proteasome system, a critical mechanism for protein quality control. By hydrolyzing ubiquitin linkages, it prevents the accumulation of free polyubiquitin chains, which could otherwise interfere with proteasomal activity. Using a USP5 antibody enables researchers to evaluate its expression patterns, subcellular localization, and functional involvement in ubiquitin dynamics. Dysregulation of USP5 has been linked to several disease processes. Elevated USP5 expression has been associated with tumor progression in cancers such as glioblastoma, colorectal cancer, and pancreatic cancer, where it contributes to cell proliferation and survival. It has also been implicated in neurological disorders due to its role in protein turnover, highlighting its importance in both health and disease. Investigating these roles with a USP5 antibody provides valuable insights into its potential as a biomarker or therapeutic target. NSJ Bioreagents offers a high-quality USP5 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Selecting a USP5 antibody from NSJ Bioreagents ensures reliable results and reproducibility in studies focused on the ubiquitin-proteasome pathway, cancer biology, and protein regulation.