Anti-USP30

Item number	Size	Manual	Delivery time	Price
E-AB-65973.60	60 µl	-	7 - 16 business days*	243.00€
E-AB-65973.120	120 µl	-	7 - 16 business days*	389.00€
E-AB-65973.200	200 µl	-	7 - 16 business days*	645.00€

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USP30, a member of the ubiquitin-specific protease family , is a novel mitochondrial... more

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Product information "Anti-USP30"

USP30, a member of the ubiquitin-specific protease family , is a novel mitochondrial deubiquitinating (DUB) enzyme. Protein function: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. [The UniProt Consortium]

Keywords:	Anti-Ub-specific protease 30, Anti-Ubiquitin thioesterase 30, Anti-Deubiquitinating enzyme 30, Anti-Ubiquitin carboxyl-terminal hydrolase 30, Anti-Ubiquitin-specific-processing protease 30, USP30 Polyclonal Antibody
Supplier:	Elabscience
Supplier-Nr:	E-AB-65973

Properties

Application:	IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant fusion protein of human USP30 (NP_116052.2).