Anti-USP30

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA016952.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA016952.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts... more

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Product information "Anti-USP30"

Protein function: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 83% and to rat: 81%

Keywords:	Anti-Ub-specific protease 30, Anti-Ubiquitin thioesterase 30, Anti-Deubiquitinating enzyme 30, Anti-Ubiquitin carboxyl-terminal hydrolase 30, Anti-Ubiquitin-specific-processing protease 30
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA016952

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: IEAKGTLNGE KVEHQRTTFV KQLKLGKLPQ CLCIHLQRLS WSSHGTPLKR HEHVQFNEFL MMDIYKYHLL GHKPSQHNPK LNKNPGPTLE LQDGPGAPTP VLNQPGAPKT QIFMNGACSP SLLPTLSAPM PFPLPVVPDY SSST (ATA-APrEST70812)