Anti-Ubiquitin-conjugating Enzyme E2C / UBCH10, clone CPTC-UBE2C-1

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Positive Control: HeLa, Jurkat or A431 cells. Human tonsil or placenta tissue. Chromosome Location: 20q13.12. Protein Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit [The Uniprot Consortium]