Anti-Ubiquitin Conjugating Enzyme E2 C [R08-4F5] Monoclonal Antibody

Ubiquitin Conjugating Enzyme E2 C Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit [The Uniprot Consortium]