Anti-Tumor Necrosis Factor alpha (TNF-a) (dolphin)

The Dolphin TNF alpha polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Dolphin TNF alpha ELISA. The Dolphin TNF alpha polyclonal antibody was produced in goats and is antigen-affinity purified. The reactivity by species is: (Bovine TNF-alpha - Weak) (Canine TNF-alpha - None) (Caprine TNF-alpha - None) (Cynomolgus Monkey TNF-alpha - None) (Dolphin TNF-alpha - Strong) (Equine TNF-alpha - None) (Feline TNF-alpha - None) (Guinea Pig TNF-alpha - None) (Human TNF-alpha - None) (Mouse TNF-alpha - None) (Ovine TNF-alpha - None) (Rabbit TNF-alpha - Weak) (Swine TNF-alpha - Weak). For research use only. Made in the USA Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. [The UniProt Consortium]