Anti-TTLL12 / Tubulin Tyrosine Ligase Like 12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
NSJ-RQ7797	100 µg		-	-	7 - 12 business days*		790.00€

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0.5mg/ml if reconstituted with 0.2ml sterile DI water. Enables H4K20me3 modified histone binding... more

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Product information "Anti-TTLL12 / Tubulin Tyrosine Ligase Like 12"

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm. Protein function: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). [The UniProt Consortium]

Keywords:	Anti-TTLL12, Anti-KIAA0153, Anti-Tubulin--tyrosine ligase-like protein 12, Anti-Inactive tubulin--tyrosine ligase-like protein 12, TTLL12 Antibody / Tubulin Tyrosine Ligase Like 12
Supplier:	NSJ Bioreagents
Supplier-Nr:	RQ7797

Properties

Application:	WB, FC, IHC (paraffin), Direct ELISA
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	E. coli-derived recombinant human protein (amino acids E8-Q634)
Format:	Posttranslational Mod.