Anti-TTLL12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA003054.25	25 µl		-		3 - 8 business days*		369.00€
ATA-HPA003054.100	100 µl		-		3 - 8 business days*		491.00€

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Protein function: Negatively regulates post-translational modifications of tubulin, including... more

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Product information "Anti-TTLL12"

Protein function: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 89% and to rat: 85%

Keywords:	Anti-TTLL12, Anti-KIAA0153, Anti-Tubulin--tyrosine ligase-like protein 12, Anti-Inactive tubulin--tyrosine ligase-like protein 12
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA003054

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: DYEKHFTVMN YDPDVVLKQV HCEEFIPEFE KQYPEFPWTD VQAEIFRAFT ELFQVACAKP PPLGLCDYPS SRAMYAVDLM LKWDNGPDGR RVMQPQILEV NFNPDCERAC RYHPTFFNDV FSTLFLDQPG (ATA-APrEST73559)