Anti-TSH Receptor / TSHR

0.5mg/ml if reconstituted with 0.2ml sterile DI water. TSH Receptor Antibody targets Thyrotropin receptor, encoded by the TSHR gene. Thyrotropin receptor is a G protein-coupled receptor primarily localized to the plasma membrane of thyroid follicular epithelial cells, where it serves as the principal mediator of thyroid-stimulating hormone signaling. As a member of the class A rhodopsin-like GPCR family, Thyrotropin receptor plays a central role in regulating thyroid gland development, hormone synthesis, and iodine uptake, making it a key control point in endocrine physiology.Functionally, Thyrotropin receptor is activated upon binding of thyroid-stimulating hormone, triggering coupling to Gs proteins and stimulation of adenylate cyclase. This leads to increased intracellular cyclic AMP levels and downstream activation of signaling cascades that regulate transcription of genes involved in thyroxine and triiodothyronine biosynthesis. In addition to canonical cAMP signaling, TSHR can engage alternative pathways involving phospholipase C and MAPK signaling, depending on cellular context and receptor conformation. A TSH Receptor Antibody is therefore useful for studies examining GPCR signaling dynamics, endocrine regulation, and receptor-mediated transcriptional control.Expression of Thyrotropin receptor is highest in thyroid tissue, particularly within differentiated follicular cells, but lower level expression has also been reported in extrathyroidal tissues such as adipose tissue, bone, and immune-related cells. Subcellular localization is predominantly at the cell surface, consistent with its role as a hormone receptor, although intracellular pools may be observed during receptor biosynthesis, trafficking, or ligand-induced internalization. These localization patterns are often explored to better understand receptor regulation and signal attenuation mechanisms.From a disease relevance perspective, Thyrotropin receptor is a major autoantigen in autoimmune thyroid disorders. Autoantibodies directed against TSHR can act as receptor agonists or antagonists, leading to dysregulated thyroid hormone production. Activating antibodies are strongly associated with Graves disease, where persistent receptor stimulation drives hyperthyroidism, while blocking antibodies are implicated in certain forms of hypothyroidism. Alterations in TSHR expression or signaling have also been explored in thyroid nodules and thyroid carcinomas, highlighting the receptor's broader relevance to thyroid pathology.At the molecular level, Thyrotropin receptor contains a large extracellular N-terminal domain responsible for ligand and autoantibody binding, seven transmembrane helices characteristic of GPCRs, and intracellular regions that mediate G protein coupling and regulatory interactions. Antibody-based detection of Thyrotropin receptor supports research focused on thyroid hormone regulation, autoimmune mechanisms, and GPCR biology. NSJ Bioreagents provides reagents intended for research use to support investigations involving Thyrotropin receptor expression and signaling.