Anti-TRPS1 Rabbit (Clone RM518)

TRPS1 is a member of the GATA-like family of zinc finger transcription factors. It is composed of seven zinc-finger domains, a cysteine-rich region, a GATA-like zinc-finger domain, and two Ikaros-like zinc-finger domains. TRPS1 is ubiquitously expressed and found in the nucleus where it binds GATA-binding sequences and functions as a transcriptional repressor. It is involved in organ development, cell cycle regulation and progression, and the regulation of bone and tooth mineralization. Deletion or loss-of-function mutations in TRPS1 are associated with Langer-Giedion syndrome, also known as trichorhinophalangeal syndrome type 1, a condition characterized by learning disabilities, craniofacial abnormalities, ectodermal dysplasia, hip malformations, and decreased stature. Cayman's TRPS1 Rabbit Monoclonal Antibody (Clone RM518) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.. Cross reactivity: (+) TRPS1: . (+) Human: (+) Mouse, (+) Rat.. Protein function: Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. [The UniProt Consortium]