Anti-TRIP12

Anti-TRIP12
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-814A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-814A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-814A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD)... more
Product information "Anti-TRIP12"
Protein function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. [The UniProt Consortium]
Keywords: Anti-ULF, Anti-TRIP12, Anti-TRIP-12, Anti-KIAA0045, EC=2.3.2.26, Anti-TR-interacting protein 12, Anti-E3 ubiquitin-protein ligase TRIP12, Anti-E3 ubiquitin-protein ligase for Arf, Anti-Thyroid receptor-interacting protein 12
Supplier: Bethyl Laboratories
Supplier-Nr: A301-814A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Dog, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, African Elephant, White Rhinoceros, Bactrian Camel, Naked Mole Rat, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-814A-T maps to a region between residue 75 and 125 of human thyroid hormone receptor interactor 12 using the numbering given in entry NP_004229.1 (GeneID 9320).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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