Anti-TRIM7

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA039213.25	25 µl		-		7 - 10 business days*		330.00€
ATA-HPA039213.100	100 µl		-		7 - 10 business days*		463.00€

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Protein function: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and... more

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Product information "Anti-TRIM7"

Protein function: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon. Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 86% and to rat: 83%

Keywords:	Anti-GNIP, Anti-TRIM7, Anti-RING finger protein 90, Anti-Glycogenin-interacting protein, Anti-E3 ubiquitin-protein ligase TRIM7, Anti-Tripartite motif-containing protein 7
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA039213

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LRVLKKELED CEVFRSTEKK ESKELLKQMA AEQEKVGAEF QALRAFLVEQ EGRLLGRLEE LSREVAQKQN ENLAQLGVEI TQLSKLSSQI (ATA-APrEST80037)