Anti-TRIM10 / Tripartite motif-containing protein 10

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TRIM10 antibody detects Tripartite motif-containing protein 10, encoded by the TRIM10 gene on chromosome 6p21.33. TRIM10 antibody is widely used in immunology and hematology research because TRIM10 belongs to the TRIM family of E3 ubiquitin ligases and is primarily expressed in hematopoietic tissues. The TRIM family is characterized by a conserved tripartite motif containing a RING finger domain, one or two B-box domains, and a coiled-coil domain. These proteins regulate diverse processes including transcription, apoptosis, innate immunity, and cell differentiation.Structurally, TRIM10 is a ~56 kDa protein composed of the canonical TRIM architecture. The RING domain confers E3 ligase activity, mediating ubiquitination of substrate proteins, while the B-box and coiled-coil regions support oligomerization and protein interactions. Alternative splicing generates isoforms with distinct functions or expression profiles. TRIM10 localizes to the cytoplasm, particularly in erythroid progenitor cells.Functionally, TRIM10 is associated with hematopoietic differentiation, particularly erythropoiesis. It regulates stability of key transcription factors and signaling proteins involved in red blood cell maturation. Knockdown studies suggest that TRIM10 contributes to erythroid lineage specification by regulating nuclear factor activity. Researchers use TRIM10 antibody to study erythropoiesis, ubiquitin signaling, and TRIM family protein biology.Clinically, TRIM10 has been implicated in blood disorders and immune regulation. Genetic variations in TRIM10 are located within the major histocompatibility complex (MHC) region, linking it to immune-related phenotypes. Altered TRIM10 expression has been observed in leukemias, suggesting a role in hematologic malignancies. As an E3 ligase, TRIM10 could be a therapeutic target in disorders of erythroid differentiation or immune dysfunction. NSJ Bioreagents supplies TRIM10 antibody for research in hematology, immunology, and oncology.Experimentally, TRIM10 antibody is used in western blotting to detect the ~56 kDa protein, in immunohistochemistry to study expression in bone marrow, and in immunofluorescence microscopy to assess cytoplasmic localization. Co-immunoprecipitation with TRIM10 antibody identifies ubiquitination substrates and TRIM family interaction partners.