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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES8147.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES8147.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The initiation of transcription is controlled in part by a large protein assembly known as the... more
Product information "Anti-TRAP230"
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009], Protein function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.. Cellular localization: Nucleus .
Keywords: | Anti-MED12, Anti-ARC240, Anti-Trap230, Anti-CAG repeat protein 45, Anti-OPA-containing protein, Anti-Mediator complex subunit 12, Anti-Activator-recruited cofactor 240 kDa component, Anti-Trinucleotide repeat-containing gene 11 protein, TRAP230 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES8147 |
Properties
Application: | IHC, IF, WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
Immunogen: | The antiserum was produced against synthesized peptide derived from human MED12. AA range:611-660 |
Format: | Antiserum |
Database Information
KEGG ID : | K15162 | Matching products |
UniProt ID : | Q93074 | Matching products |
Gene ID | GeneID 9968 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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