Anti-TRAP-1 / HSP75

Anti-TRAP-1 / HSP75
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32204 100 µg - -

3 - 10 business days

503.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Heat shock protein 75 kDa, mitochondrial... more
Product information "Anti-TRAP-1 / HSP75"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene. It is mapped to 16p13.3. This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. And this protein may function in regulating cellular stress responses. In addition, it was found that TRAP1 interacted with the N-terminal half of TNFR1. Also, TRAP1 interacted with the C-terminal ends of the proteins encoded by both multiple exostoses-causing genes, EXT1 and EXT2, but not with EXTL1 or EXTL3. Protein function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. [The UniProt Consortium]
Keywords: Anti-HSP75, Anti-TRAP1, Anti-HSP 75, Anti-TRAP-1, Anti-TNFR-associated protein 1, Anti-Heat shock protein 75 kDa, mitochondrial, Anti-Tumor necrosis factor type 1 receptor-associated protein, TRAP-1 Antibody / HSP75
Supplier-Nr: R32204

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Rat
Immunogen: Amino acids 571-704 of human TRAP1 were used as the immunogen for the TRAP1 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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