Anti-Transferrin Receptor / CD71, clone DF1513

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG56159.50 50 µg - -

6 - 14 business days*

608.00€
 
Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of... more
Product information "Anti-Transferrin Receptor / CD71, clone DF1513"
Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). [The UniProt Consortium]
Keywords: Anti-TFRC
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG56159

Properties

Application: FC, ICC, IF, WB
Antibody Type: Monoclonal
Clone: DF1513
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: KG1 acute myeloid leukemia cell line
MW: 85 - 95 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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