Anti-Transferrin Receptor, clone DF1513

Anti-Transferrin Receptor, clone DF1513
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2260-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V2260-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes a... more
Product information "Anti-Transferrin Receptor, clone DF1513"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa (Workshop IV). The antibody is highly specific to transferrin receptor and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. [The UniProt Consortium]
Keywords: Anti-TFRC, Transferrin Receptor Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2260

Properties

Application: WB, FC, IF
Antibody Type: Monoclonal
Clone: DF1513
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: The KG1 acute myeloid leukemia cell line was used as the immunogen for this Transferrin receptor / CD71 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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