Anti-Transferrin Receptor (CD71), clone TFRC/1059

Anti-Transferrin Receptor (CD71), clone TFRC/1059
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2881SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes a ~90-95kDa protein which is... more
Product information "Anti-Transferrin Receptor (CD71), clone TFRC/1059"
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This mAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. [The UniProt Consortium]
Keywords: Anti-TFRC, Transferrin Receptor Antibody (CD71)
Supplier: NSJ Bioreagents
Supplier-Nr: V2881SAF-100UG

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: TFRC/1059
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human TFRC protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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