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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T9161-66.100 | 100 µg | - | - |
3 - 19 business days* |
644.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR)... more
Product information "Anti-TRAF6, CT (Tumor Necrosis Factor Receptor Associated Factor 6)"
Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kB (1,2). TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families (3). TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands (4). It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) (5) or by other TLR adaptor molecules such as TRIF (6). Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK (7). Applications: Can be used for detection of TRAF6 by Western blot at 1 to 2ug/ml. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | EC=6.3.2.-, Anti-RNF85, Anti-TRAF6, Anti-RING finger protein 85, Anti-Interleukin-1 signal transducer, Anti-TNF receptor-associated factor 6, Anti-E3 ubiquitin-protein ligase TRAF6 |
Supplier: | United States Biological |
Supplier-Nr: | T9161-66 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Peptide corresponding to 14 amino acids near the C-terminus of human TRAF6 (GenBank accession no. S71821) |
Format: | Highly Purified |
Database Information
KEGG ID : | K03175 | Matching products |
UniProt ID : | Q9Y4K3 | Matching products |
Gene ID | GeneID 7189 | Matching products |
Handling & Safety
Storage: | -20°C (frozen cool packs) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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