Anti-TRAF1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. TNF Receptor-Associated Factor 1, also called EBI6, is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. Siemienski et al.(1997) used fluorescence in situ hybridization to map the gene to 9q33-q34. Mosialos et al.(1995) found that LMP1, the EBV-transforming protein, specifically associates with LAP1 (TRAF3) or TRAF1 in B lymphoblasts. LMP1 expression redirects LAP1 and TRAF1 from scattered cytoplasmic structures to LMP1 plasma membrane patches. Both LAP1 and TRAF1 associated with the cytoplasmic domain of p80/TNFR2 in vivo. Protein function: Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. [The UniProt Consortium]