Anti-TPX2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA005487.25	25 µl		-		3 - 8 business days*		246.00€
ATA-HPA005487.100	100 µl		-		3 - 8 business days*		491.00€

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Protein function: Spindle assembly factor required for normal assembly of mitotic spindles.... more

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Product information "Anti-TPX2"

Protein function: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 84% and to rat: 86%

Keywords:	Anti-p100, Anti-TPX2, Anti-DIL-2, Anti-C20orf1, Anti-Protein fls353, Anti-Targeting protein for Xklp2, Anti-Hepatocellular carcinoma-associated antigen 90, Anti-Hepatocellular carcinoma-associated antigen 519
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA005487

Properties

Application:	WB, IHC, ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QELEKSMKMQ QEVVEMRKKN EEFKKLALAG IGQPVKKSVS QVTKSVDFHF RTDERIKQHP KNQEEYKEVN FTSELRKHPS SPARVTKGCT IVKPFNLSQG KKRTFDETVS TYVPLAQQVE DFHKRTPNRY HLRSKKD (ATA-APrEST86576)