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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2541SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes a 63kDa protein, which is... more
Product information "Anti-TOX3, clone TOX3/1123"
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts. Protein function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. [The UniProt Consortium]
Keywords: | Anti-TOX3, Anti-CAGF9, Anti-TOX high mobility group box family member 3, Anti-Trinucleotide repeat-containing gene 9 protein, Anti-CAG trinucleotide repeat-containing gene F9 protein, TOX3 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2541SAF |
Properties
Application: | FC, IF, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | TOX3/1123 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A 139 amino acid partial recombinant protein (between AA 200-400) from human TOX3 |
Format: | Purified |
Database Information
UniProt ID : | O15405 | Matching products |
Gene ID | GeneID 27324 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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