Anti-TopBP1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-111A-T	10 µl (10 µg)		-		2 - 8 business days*		165.00€
A300-111A	100 µl (100 µg)		-		2 - 8 business days*		586.00€

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Protein function: Required for DNA replication. Plays a role in the rescue of stalled replication... more

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Product information "Anti-TopBP1"

Protein function: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). [The UniProt Consortium]

Keywords:	Anti-TOPBP1, Anti-TopBP1, Anti-KIAA0259, Anti-DNA topoisomerase 2-binding protein 1, Anti-DNA topoisomerase II-binding protein 1, Anti-DNA topoisomerase II-beta-binding protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-111A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: orangutan, gorilla, chimpanzee, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-111A-T maps to a region between residue 1400 and the C-terminus (residue 1435) of human Topoisomerase (DNA) II Binding Protein 1 using the numbering given in entry NP_008958.1 (GeneID 11073).
Format:	Antigen Affinity Purified