Anti-TNS4 / Tensin 4

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TNS4 antibody detects Tensin-4, encoded by the TNS4 gene on chromosome 17q12. TNS4 antibody is widely used in studies of adhesion, migration, and cancer biology. Tensin-4, also known as C-terminal tensin-like protein (Cten), is part of the tensin family of actin-binding proteins localized to focal adhesions. Unlike other tensin family members, TNS4 lacks an actin-binding domain, functioning primarily as an adaptor linking integrins and signaling proteins. It is expressed in epithelial tissues and is frequently upregulated in cancers, where it promotes motility and invasion.Structurally, Tensin-4 contains SH2 and PTB domains that mediate binding to phosphorylated proteins and integrins. It localizes to focal adhesions, interacting with integrin tails and signaling molecules such as Src and PI3K. Its lack of an actin-binding domain differentiates it from Tensin-1, -2, and -3, conferring specialized signaling roles rather than structural crosslinking.Functionally, TNS4 regulates focal adhesion dynamics and integrin signaling. By linking integrins to signaling pathways, it promotes cell motility, survival, and epithelial-mesenchymal transition (EMT). Knockdown reduces migration and invasion, while overexpression enhances metastatic potential. TNS4 also influences growth factor receptor signaling, contributing to proliferation and survival. Researchers use TNS4 antibody to study focal adhesion biology, integrin signaling, and cancer metastasis.Clinically, TNS4 is a biomarker and driver of cancer progression. It is overexpressed in colorectal, breast, pancreatic, and lung cancers, correlating with poor prognosis. Its expression enhances invasion and resistance to apoptosis, making it a therapeutic target in oncology. Beyond cancer, TNS4 participates in wound healing by promoting migration of epithelial cells. NSJ Bioreagents provides TNS4 antibody for oncology and adhesion research.Experimentally, TNS4 antibody is applied in western blotting to detect the ~80 kDa protein, in immunohistochemistry to study tumor expression, and in immunofluorescence microscopy to analyze focal adhesion localization. Co-immunoprecipitation with TNS4 antibody identifies integrin and signaling partners, revealing mechanisms of adhesion regulation.