Anti-TNS3 / Tensin 3

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TNS3 antibody detects Tensin-3, a cytoskeletal adaptor protein that links integrins to the actin cytoskeleton and participates in cell adhesion, migration, and signal transduction. Encoded by the TNS3 gene on chromosome 7p12.3, this protein is part of the tensin family, which plays key roles in focal adhesion dynamics and mechanical signal integration. Tensin-3 contributes to the structural connection between integrin-mediated extracellular matrix adhesion sites and intracellular actin filaments, regulating cellular shape and motility.Structurally, Tensin-3 contains Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains that interact with phosphorylated tyrosine residues on focal adhesion proteins and with integrin cytoplasmic tails. Through these domains, TNS3 facilitates recruitment of signaling molecules, including Src family kinases, PI3K, and FAK, at adhesion sites. It also modulates Rho GTPase signaling, influencing actin organization and cell polarity.The TNS3 antibody is widely used in cancer biology, cytoskeletal research, and cell signaling studies to investigate adhesion remodeling and integrin signaling. Western blot analysis detects a 150-160 kilodalton band corresponding to Tensin-3, while immunofluorescence reveals focal adhesion and cytoplasmic localization. This antibody supports studies examining adhesion turnover, migration, and mechanotransduction pathways in normal and malignant cells.Tensin-3 expression is frequently altered in cancer, where it influences metastatic potential and invasion by regulating focal adhesion stability and actin remodeling. Overexpression promotes invasive behavior in several carcinoma types, while loss of function impairs migration and cell spreading. The TNS3 antibody provides a reliable reagent for exploring adhesion-mediated signaling and tumor cell motility. NSJ Bioreagents offers this antibody validated for western blotting, immunohistochemistry, and immunofluorescence, ensuring reproducible detection for cytoskeletal and signaling research.