Anti-TNFSF4 Chimeric Monoclonal Antibody (Clone R4930 (Oxelumab))

TNF ligand superfamily member 4 (TNFSF4), also known as OX40L, is a type II transmembrane protein and the cognate ligand of the T cell co-stimulatory TNF receptor TNFRSF4, also known as OX40. TNFSF4 assembles into trimers, with each monomer possessing an approximately 132-amino acid extracellular domain composed of a TNF homology domain followed by a C-terminal extension. It is upregulated in antigen-presenting cells, including B cells, macrophages, and dendritic cells, in response to antigen presentation, and is also expressed in mast cells, activated T cells, and certain endothelial cells. Binding of a TNFSF4 trimer to three TNFRSF4 monomers promotes T cell survival and memory, as well as an effector T cell phenotype, enhances cell mobility, and increases the production of effector cytokines. Polymorphisms in TNFSF4 are associated with susceptibility to systemic lupus erythematosus (SLE) and systemic sclerosis. Cayman's TNFSF4 Chimeric Monoclonal Antibody (Clone R4930 (Oxelumab)) was recombinantly generated based on the sequence of the original humanized anti-TNFSF4 antibody and can be used for flow cytometry (FC). The humanized anti-TNFSF4 antibody was generated by immunizing HCo12 human IgG transgenic mice with alternating administration of recombinant human TNFSF4 and human TNSF4-expressing cells.Synonyms: CD134L, CD252, Glycoprotein Gp34, OX40 Ligand, OX40L, TAX Transcriptionally Activated Glycoprotein 1, Tumor Necrosis Factor Ligand Superfamily Member 4, TXGP1. Immunogen: Recombinant human TNFSF4 and human TNSF4-expressing cells. Clone Designation: R4930 (Oxelumab). Formulation: (Request formulation change), 200 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 0.02% ProClin(TM) 300. Host: Chimeric monoclonal antibody. Isotype: IgG1?. Applications: FC, block. Cross Reactivity: (+) TNFSF4. UniProt Accession #: P23510.