Anti-TNFAIP2 / Tumor necrosis factor alpha-induced protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TNFAIP2 antibody detects Tumor necrosis factor alpha-induced protein 2, encoded by the TNFAIP2 gene on chromosome 14q32.33. TNFAIP2 antibody is widely used in studies of inflammation, immune signaling, and cancer biology. TNFAIP2 is a cytoplasmic and membrane-associated protein strongly induced by TNF-alpha, IL-1, and NF-kappaB signaling. It contributes to vesicle trafficking, endothelial cell function, and tumor progression, reflecting its broad roles in immunity and disease.Structurally, TNFAIP2 is a ~73 kDa protein with coiled-coil regions and proline-rich motifs that mediate interactions with cytoskeletal proteins and membrane trafficking machinery. It localizes to filopodia, lamellipodia, and endosomal membranes. Through these domains, TNFAIP2 regulates cytoskeletal remodeling and exosome release.Functionally, TNFAIP2 supports endothelial cell migration, tube formation, and angiogenesis. It is a critical factor in immune cell adhesion and transmigration across vascular barriers. In cancer, TNFAIP2 promotes tumor growth, invasion, and metastasis partly by regulating exosome biogenesis and secretion of pro-tumorigenic factors. Researchers use TNFAIP2 antibody to study immune responses, inflammation, and cancer progression.Clinically, TNFAIP2 is implicated in nasopharyngeal carcinoma, glioma, and other cancers. Elevated expression correlates with poor prognosis, invasive potential, and chemoresistance. TNFAIP2 is also linked to inflammatory vascular diseases and sepsis, where it modulates leukocyte-endothelial interactions. Because of its role in exosome release, TNFAIP2 is being explored as a therapeutic target in oncology. NSJ Bioreagents provides TNFAIP2 antibody to support research in immunology, oncology, and translational biology.Experimentally, TNFAIP2 antibody is applied in western blotting to detect the ~73 kDa protein, in immunofluorescence to visualize filopodial localization, and in immunohistochemistry to analyze tumor expression. Co-immunoprecipitation with TNFAIP2 antibody helps identify vesicle trafficking partners.