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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| AG-20B-0081PF-TRIAL | 25 µg | - |
3 - 6 business days* |
160.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Functional Application: Inhibition of mouse TNF-a function in vivo (in mice). 20µg of... more
Product information "Anti-TNF-alpha (mouse), mAb (blocking) (V1q) (preservative free)"
Functional Application: Inhibition of mouse TNF-a function in vivo (in mice). 20µg of antibody/mouse is sufficient to block the activity of endogenous mouse TNF-alpha. Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176). [The UniProt Consortium]
| Keywords: | Anti-Tnf, Anti-Tnfa |
| Supplier: | AdipoGen Life Sciences |
| Supplier-Nr: | AG-20B-0081PF |
Properties
| Application: | FA, FC |
| Antibody Type: | Monoclonal |
| Clone: | V1q |
| Conjugate: | No |
| Host: | Rat |
| Species reactivity: | mouse |
| Immunogen: | Cytotoxin purified from ConA induced T cell clone 29 |
| Purity: | >95% (SDS PAGE) |
| Format: | Purified |
Database Information
| KEGG ID : | K03156 | Matching products |
| UniProt ID : | P06804 | Matching products |
| Gene ID : | GeneID 21926 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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